Tissue expression
Cell line expression
Protein structure
ADSL
Adenylosuccinate lyaseThe protein encoded by this gene belongs to the lyase 1 family. It is an essential enzyme involved in purine metabolism, and catalyzes two non-sequential reactions in the de novo purine biosynthetic pathway: the conversion of succinylaminoimidazole carboxamide ribotide (SAICAR) to aminoimidazole carboxamide ribotide (AICAR) and the conversion of adenylosuccinate (S-AMP) to adenosine monophosphate (AMP). Mutations in this gene are associated with adenylosuccinase deficiency (ADSLD), a disorder marked with psychomotor retardation, epilepsy or autistic features. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]
Top validated antibodies |
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Atlas Antibodies | HPA000525 | 2 references | Polyclonal |
WB
ICC
IHC
|
|
Proteintech Group | 15264-1-AP | 2 references | Polyclonal |
WB
EL
ICC
IHC
FC
|
|
Invitrogen Antibodies | 15264-1-AP | Polyclonal |
WB
ICC
IHC
FC |
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Novus Biologicals | NBP1-87406 | 2 references | Polyclonal |
WB
ICC
IHC
|
|
NovoPro Bioscience Inc. | 107785 | Polyclonal |
WB
EL
ICC
IHC
FC
|
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