Tissue expression
Cell line expression
Protein structure
AMACR
Alpha-methylacyl-CoA racemaseP504S, RACE
This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. [provided by RefSeq, Mar 2011]
Top validated antibodies |
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antibodies-online | ABIN950388 | 5 references | Polyclonal |
WB
ICC
IHC
FC |
|
Proteintech Group | 15918-1-AP | 2 references | Polyclonal |
WB
EL
IHC
|
|
Abgent | AP10110b | Polyclonal |
WB
ICC
IHC
FC |
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OriGene | AP50158PU-N | Polyclonal |
WB
ICC
IHC
FC |
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Acris Antibodies GmbH | AP50158PU-N | Polyclonal |
WB
ICC
IHC
FC |
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