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Protein structure
CNTF
Ciliary neurotrophic factorHCNTF
The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010]
Top validated antibodies |
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| R&D Systems |  AB-557-NA |
1 references | Polyclonal |
WB
IHC
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| Novus Biologicals | AB-557-NA |
1 references | Polyclonal |
WB
IHC
BN
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| GeneTex | GTX74106 |
Polyclonal |
WB
EL
ICC
IHC
FA
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| Proteintech Group | 27342-1-AP |
1 references | Polyclonal |
EL
ICC
IHC
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| Invitrogen Antibodies | 500-P140-100UG |
2 references | Polyclonal |
WB
EL
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