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Cell line expression
Protein structure
UHRF1
Ubiquitin like with PHD and ring finger domains 1FLJ21925, ICBP90, Np95, RNF106, TDRD22
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014]
Top validated antibodies |
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| GeneTex |  GTX113963 |
2 references | Polyclonal |
WB
ICC
IP
IHC
ChIP
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| Invitrogen Antibodies | PA5-29884 |
2 references | Polyclonal |
WB
ICC
IHC
ChIP
OA
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| Novus Biologicals | H00029128-M01 |
2 references | Monoclonal |
WB
EL
ICC
IP
IHC
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| Proteintech Group | 21402-1-AP |
9 references | Polyclonal |
WB
EL
ICC
IP
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| antibodies-online | ABIN393667 |
5 references | Monoclonal |
WB
EL
ICC
IHC
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