PIK3R6

Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 7. The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Description

Phosphoinositide-3-kinase regulatory subunit 6

Tissue specificity

Tissue enhanced (lymphoid tissue)

Subcell location

Nucleoplasm, Golgi apparatus, Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

17 (8802722 - 8867677)

Ensembl ID

ENSG00000276231  (ver. 103.38)

Orthologs

Mouse Pik3r6: ENSMUSG00000046207

UniProt

Q5UE93

neXtProt

NX_Q5UE93

Human splice variants
Mouse splice variants

Protein structure