ACO1

Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes. [provided by RefSeq, Jul 2008]

Description

aconitase 1, soluble

Protein family

Enzymes

Chromosome

9:p21.1 (32384618 - 32450834)

Ensembl ID

ENSG00000122729  (ver. 69.37)

Orthologs

Mouse Aco1: ENSMUSG00000028405

Human splice variants
Mouse splice variants