DNAI1

The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. This gene encodes an intermediate chain dynein, belonging to the large family of motor proteins. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia (PCD) and Kartagener syndrome. [provided by RefSeq, Jul 2008]

Description

dynein, axonemal, intermediate chain 1

Protein family

Mapped to UniProt SWISS-PROT, Potential transmembrane proteins

Chromosome

9:p13.3 (34457412 - 34520982)

Ensembl ID

ENSG00000122735  (ver. 71.37)

Orthologs

Mouse Dnaic1: ENSMUSG00000061322

Human splice variants
Mouse splice variants