ASB7

The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Description

ankyrin repeat and SOCS box containing 7

Protein family

-

Chromosome

15:q26.3 (101142739 - 101191910)

Ensembl ID

ENSG00000183475  (ver. 69.37)

Orthologs

Mouse Asb7: ENSMUSG00000030509

Human splice variants
Mouse splice variants