MATK

The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Description

megakaryocyte-associated tyrosine kinase

Protein family

Enzymes, Kinases, SH2-domain containing proteins, SH3-domain containing proteins

Chromosome

19:p13.3 (3777971 - 3802127)

Ensembl ID

ENSG00000007264  (ver. 69.37)

Orthologs

Mouse Matk: ENSMUSG00000004933

Human splice variants
Mouse splice variants