PIM1

The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810). [provided by RefSeq, Aug 2011]

Description

pim-1 oncogene

Protein family

Candidate cancer biomarkers, Enzymes, Kinases, Mapped to UniProt SWISS-PROT, Mutated genes in cancer, Potential transmembrane proteins

Chromosome

6:p21.2 (37137979 - 37143202)

Ensembl ID

ENSG00000137193  (ver. 71.37)

Orthologs

Mouse Pim1: ENSMUSG00000024014

Human splice variants
Mouse splice variants