FBXO18

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Description

F-box protein, helicase, 18

Protein family

Enzymes, Membrane proteins predicted by MDM

Chromosome

10:p15.1 (5931535 - 5979556)

Ensembl ID

ENSG00000134452  (ver. 69.37)

Orthologs

Mouse Fbxo18: ENSMUSG00000058594

Human splice variants
Mouse splice variants