CHN2

This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Description

chimerin 2

Protein family

Mapped to UniProt SWISS-PROT, SH2-domain containing proteins

Chromosome

7:p14.3 (29161956 - 29553944)

Ensembl ID

ENSG00000106069  (ver. 71.37)

Orthologs

Mouse Chn2: ENSMUSG00000004633

Human splice variants
Mouse splice variants