ATF4

This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]

Description

activating transcription factor 4 (tax-responsive enhancer element B67)

Protein family

Transcription factors

Chromosome

22:q13.1 (39915700 - 39918691)

Ensembl ID

ENSG00000128272  (ver. 69.37)

Orthologs

Mouse Atf4: ENSMUSG00000042406

Human splice variants
Mouse splice variants