LTBP1

The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Description

latent transforming growth factor beta binding protein 1

Protein family

Mapped to UniProt SWISS-PROT, Potential transmembrane proteins, Potentially secreted proteins

Chromosome

2:p22.3 (33172039 - 33624576)

Ensembl ID

ENSG00000049323  (ver. 71.37)

Orthologs

Mouse Ltbp1: ENSMUSG00000001870

Human splice variants
Mouse splice variants