EMR2

This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 3 on chromosome 19. This protein does not interact with the ligand decay accelerating factor for complement, unlike the related CD97 antigen, and indicates that these very closely related proteins likely have nonredundant functions. This gene results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Description

egf-like module containing, mucin-like, hormone receptor-like 2

Protein family

CD markers, GPCRs excl olfactory receptors, Membrane proteins predicted by MDM, Secreted proteins predicted by MDSP

Chromosome

19:p13.12 (14843205 - 14889353)

Ensembl ID

ENSG00000127507  (ver. 69.37)

Orthologs

-

Human splice variants