GPR56
gene productTM7LN4, TM7XN1
This gene encodes a member of the G protein-coupled receptor family. The protein contains 7 transmembrane domains and a mucin-like domain in the N-terminal region. The gene is implicated in the regulation of brain cortical patterning. The protein binds specifically to transglutaminase 2 in the extracellular space. Expression of this gene is downregulated in melanoma cell lines, and overexpression of this gene can suppress tumor growth and metastasis. Mutations in this gene result in bilateral frontoparietal polymicrogyria. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
- Description
- G protein-coupled receptor 56
- Protein family
- GPCRs excl olfactory receptors, Membrane proteins predicted by MDM, Secreted proteins predicted by MDSP
- Chromosome
- 16:q21 (57644564 - 57698944)
- Ensembl ID
- ENSG00000205336 (ver. 69.37)
- Orthologs
- Mouse Gpr56: ENSMUSG00000031785
Human splice variants
Mouse splice variants
| Ensembl | UniProt | RefSeq | Entrez |
|---|---|---|---|
|
ENSMUST00000093271 ENSMUSP00000090959 |
GPR56_MOUSE Q8K209 | NP_061370.2 NP_061370 NP_001185823.1 NP_001185823 | Gpr56 14766 |
|
ENSMUST00000179619 ENSMUSP00000137520 |
NP_061370.2 NP_061370 NP_001185823.1 NP_001185823 | Gpr56 14766 |
Antibodies
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