HARS

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Description

histidyl-tRNA synthetase

Protein family

Enzymes

Chromosome

5:q31.3 (140052758 - 140071609)

Ensembl ID

ENSG00000170445  (ver. 69.37)

Orthologs

Mouse Hars: ENSMUSG00000001380

Human splice variants
Mouse splice variants