PAK4

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

p21 protein (Cdc42/Rac)-activated kinase 4

Protein family

Enzymes, Kinases, Mapped to UniProt SWISS-PROT, Potential transmembrane proteins

Chromosome

19:q13.2 (39616410 - 39673456)

Ensembl ID

ENSG00000130669  (ver. 71.37)

Orthologs

Mouse Pak4: ENSMUSG00000030602

Human splice variants
Mouse splice variants