F11

This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]

Description

coagulation factor XI

Protein family

Candidate cardiovascular disease genes, Enzymes, Mapped to UniProt SWISS-PROT, Peptidases, Plasma proteins, Potential transmembrane proteins, Potentially secreted proteins

Chromosome

4:q35.2 (187187099 - 187210835)

Ensembl ID

ENSG00000088926  (ver. 71.37)

Orthologs

Mouse F11: ENSMUSG00000031645

Human splice variants
Mouse splice variants