KCNQ4

The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

potassium voltage-gated channel, KQT-like subfamily, member 4

Protein family

Mapped to UniProt SWISS-PROT, Potential transmembrane proteins, Potentially secreted proteins, Transporters, Voltage-gated ion channels

Chromosome

1:p34.2 (41249684 - 41306124)

Ensembl ID

ENSG00000117013  (ver. 71.37)

Orthologs

Mouse Kcnq4: ENSMUSG00000028631

Human splice variants
Mouse splice variants