CASP4

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Description

caspase 4, apoptosis-related cysteine peptidase

Protein family

Enzymes, Peptidases

Chromosome

11:q22.3 (104813593 - 104840163)

Ensembl ID

ENSG00000196954  (ver. 69.37)

Orthologs

-

Human splice variants