ABCC3

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Description

ATP-binding cassette, sub-family C (CFTR/MRP), member 3

Protein family

Membrane proteins predicted by MDM, Transporters

Chromosome

17:q21.33 (48712138 - 48769613)

Ensembl ID

ENSG00000108846  (ver. 69.37)

Orthologs

Mouse Abcc3: ENSMUSG00000020865

Human splice variants
Mouse splice variants