HABP2

The protein encoded by this gene is an extracellular serine protease that binds hyaluronic acid and is involved in cell adhesion. The encoded protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This protease is known to cleave urinary plasminogen activator, coagulation factor VII, and the alpha and beta chains of fibrinogen, but not prothrombin, plasminogen, or the gamma chain of fibrinogen. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

Description

hyaluronan binding protein 2

Protein family

Peptidases, Secreted proteins predicted by MDSP

Chromosome

10:q25.3 (115310596 - 115349361)

Ensembl ID

ENSG00000148702  (ver. 69.37)

Orthologs

Mouse Habp2: ENSMUSG00000025075

Human splice variants
Mouse splice variants