AVPR1B

The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known. [provided by RefSeq, Jul 2008]

Description

arginine vasopressin receptor 1B

Protein family

G-protein coupled receptors, Mapped to UniProt SWISS-PROT, Potential transmembrane proteins

Chromosome

1:q32.1 (206223976 - 206231639)

Ensembl ID

ENSG00000198049  (ver. 71.37)

Orthologs

Mouse Avpr1b: ENSMUSG00000026432

Human splice variants
Mouse splice variants