CACNA1H

This gene encodes a T-type member of the alpha-1 subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either encoded by different genes or the result of alternative splicing of transcripts. Alternate transcriptional splice variants, encoding different isoforms, have been characterized for the gene described here. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (CAE). [provided by RefSeq, Jul 2008]

Description

calcium channel, voltage-dependent, T type, alpha 1H subunit

Protein family

Membrane proteins predicted by MDM, Transporters, Voltage-gated ion channels

Chromosome

16:p13.3 (1203241 - 1271771)

Ensembl ID

ENSG00000196557  (ver. 69.37)

Orthologs

Mouse Cacna1h: ENSMUSG00000024112

Human splice variants
Mouse splice variants