TRPM5

This gene encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction, and has characteristics of a calcium-activated, non-selective cation channel that carries Na+, K+, and Cs+ ions equally well, but not Ca(2+) ions. It is activated by lower concentrations of intracellular Ca(2+), and inhibited by higher concentrations. It is also a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. This gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5, and has been shown to be imprinted, with exclusive expression from the paternal allele. [provided by RefSeq, Oct 2010]

Description

transient receptor potential cation channel, subfamily M, member 5

Protein family

Membrane proteins predicted by MDM, Transporters, Voltage-gated ion channels

Chromosome

11:p15.5 (2425745 - 2444275)

Ensembl ID

ENSG00000070985  (ver. 69.37)

Orthologs

Mouse Trpm5: ENSMUSG00000009246

Human splice variants
Mouse splice variants