CLCN4

The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins. [provided by RefSeq, Mar 2012]

Description

chloride channel, voltage-sensitive 4

Protein family

Membrane proteins predicted by MDM, Transporters

Chromosome

X:p22.2 (10125024 - 10205700)

Ensembl ID

ENSG00000073464  (ver. 69.37)

Orthologs

Mouse Clcn4-2: ENSMUSG00000000605

Human splice variants
Mouse splice variants