AKR1C1

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]

Description

aldo-keto reductase family 1, member C1

Protein family

Enzymes, Mapped to UniProt SWISS-PROT, Potentially secreted proteins

Chromosome

10:p15.1 (4934796 - 5025475)

Ensembl ID

ENSG00000187134  (ver. 71.37)

Orthologs

-

Human splice variants