ADH5

This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]

Description

alcohol dehydrogenase 5 (class III), chi polypeptide

Protein family

Enzymes

Chromosome

4:q23 (99992132 - 100009952)

Ensembl ID

ENSG00000197894  (ver. 69.37)

Orthologs

Mouse Adh5: ENSMUSG00000028138

Human splice variants
Mouse splice variants