CA4

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This gene encodes a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and proximal renal tubules. Its exact function is not known; however, it may have a role in inherited renal abnormalities of bicarbonate transport. [provided by RefSeq, Jul 2008]

Description

carbonic anhydrase IV

Protein family

Enzymes, Membrane proteins predicted by MDM, Secreted proteins predicted by MDSP

Chromosome

17:q23.1 (58227297 - 58248260)

Ensembl ID

ENSG00000167434  (ver. 69.37)

Orthologs

Mouse Car4: ENSMUSG00000000805

Human splice variants
Mouse splice variants