HCN4

This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008]

Description

hyperpolarization activated cyclic nucleotide-gated potassium channel 4

Protein family

Membrane proteins predicted by MDM, Transporters, Voltage-gated ion channels

Chromosome

15:q24.1 (73612200 - 73661605)

Ensembl ID

ENSG00000138622  (ver. 69.37)

Orthologs

Mouse Hcn4: ENSMUSG00000032338

Human splice variants
Mouse splice variants