APEX2

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair (BER). [provided by RefSeq, Jul 2008]

Description

APEX nuclease (apurinic/apyrimidinic endonuclease) 2

Protein family

Enzymes, Transcription factors

Chromosome

X:p11.21 (55026790 - 55035490)

Ensembl ID

ENSG00000169188  (ver. 69.37)

Orthologs

Mouse Apex2: ENSMUSG00000025269

Human splice variants
Mouse splice variants