A1CF

Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Description

APOBEC1 complementation factor

Protein family

-

Chromosome

10:q11.23 (52566322 - 52645435)

Ensembl ID

ENSG00000148584  (ver. 69.37)

Orthologs

Mouse A1cf: ENSMUSG00000052595

Human splice variants
Mouse splice variants