CAD

The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. [provided by RefSeq, Jul 2008]

Description

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

Protein family

Enzymes

Chromosome

2:p23.3 (27440258 - 27466660)

Ensembl ID

ENSG00000084774  (ver. 69.37)

Orthologs

Mouse Cad: ENSMUSG00000013629

Human splice variants
Mouse splice variants