MAPK11

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase. [provided by RefSeq, Jul 2008]

Description

mitogen-activated protein kinase 11

Protein family

Enzymes, Kinases

Chromosome

22:q13.33 (50702142 - 50709196)

Ensembl ID

ENSG00000185386  (ver. 69.37)

Orthologs

Mouse Mapk11: ENSMUSG00000053137

Human splice variants
Mouse splice variants