FZD6

This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide. [provided by RefSeq, Aug 2011]

Description

frizzled family receptor 6

Protein family

GPCRs excl olfactory receptors, Membrane proteins predicted by MDM, Secreted proteins predicted by MDSP

Chromosome

8:q22.3 (104310661 - 104345094)

Ensembl ID

ENSG00000164930  (ver. 69.37)

Orthologs

Mouse Fzd6: ENSMUSG00000022297

Human splice variants
Mouse splice variants