ATG4A

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Description

autophagy related 4A, cysteine peptidase

Protein family

Mapped to UniProt SWISS-PROT, Peptidases, Potential transmembrane proteins

Chromosome

X:q22.3 (107334898 - 107397901)

Ensembl ID

ENSG00000101844  (ver. 71.37)

Orthologs

Mouse Atg4a: ENSMUSG00000079418

Human splice variants
Mouse splice variants