CELSR2

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008]

Description

cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)

Protein family

GPCRs excl olfactory receptors, Membrane proteins predicted by MDM, Secreted proteins predicted by MDSP

Chromosome

1:p13.3 (109792641 - 109818377)

Ensembl ID

ENSG00000143126  (ver. 69.37)

Orthologs

Mouse Celsr2: ENSMUSG00000068740

Human splice variants
Mouse splice variants