CLK4

The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. [provided by RefSeq, Jul 2008]

Description

CDC-like kinase 4

Protein family

Enzymes, Kinases, Membrane proteins predicted by MDM

Chromosome

5:q35.3 (178029665 - 178057616)

Ensembl ID

ENSG00000113240  (ver. 69.37)

Orthologs

Mouse Clk4: ENSMUSG00000020385

Human splice variants
Mouse splice variants