EP300

This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]

Description

E1A binding protein p300

Protein family

Enzymes, Transcription factors

Chromosome

22:q13.2 (41487790 - 41576081)

Ensembl ID

ENSG00000100393  (ver. 69.37)

Orthologs

Mouse Ep300: ENSMUSG00000055024

Human splice variants
Mouse splice variants