ADAMTS18

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Description

ADAM metallopeptidase with thrombospondin type 1 motif, 18

Protein family

Peptidases, Secreted proteins predicted by MDSP

Chromosome

16:q23.1 (77281710 - 77469011)

Ensembl ID

ENSG00000140873  (ver. 69.37)

Orthologs

Mouse Adamts18: ENSMUSG00000053399

Human splice variants
Mouse splice variants