PSMB7

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon and proteolytic processing is required to generate a mature subunit. This subunit is not present in the immunoproteasome and is replaced by catalytic subunit 2i (proteasome beta 10 subunit). [provided by RefSeq, Jul 2008]

Description

proteasome (prosome, macropain) subunit, beta type, 7

Protein family

Enzymes, Peptidases

Chromosome

9:q33.3 (127115745 - 127177723)

Ensembl ID

ENSG00000136930  (ver. 69.37)

Orthologs

Mouse Psmb7: ENSMUSG00000026750

Human splice variants
Mouse splice variants