MRPL21

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding different isoforms were identified through sequence analysis although some may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]

Description

mitochondrial ribosomal protein L21

Protein family

Mapped to UniProt SWISS-PROT, Potentially secreted proteins, Ribosomal proteins

Chromosome

11:q13.3 (68658744 - 68671303)

Ensembl ID

ENSG00000197345  (ver. 71.37)

Orthologs

Mouse Mrpl21: ENSMUSG00000024829

Human splice variants
Mouse splice variants