CBFA2T3

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]

Description

core-binding factor, runt domain, alpha subunit 2; translocated to, 3

Protein family

Mapped to UniProt SWISS-PROT, Mutated genes in cancer, Potential transmembrane proteins

Chromosome

16:q24.3 (88941266 - 89043612)

Ensembl ID

ENSG00000129993  (ver. 71.37)

Orthologs

Mouse Cbfa2t3: ENSMUSG00000006362

Human splice variants
Mouse splice variants