ATP1A3

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Description

ATPase, Na+/K+ transporting, alpha 3 polypeptide

Protein family

Enzymes, Membrane proteins predicted by MDM, Transporters

Chromosome

19:q13.2 (42470734 - 42498384)

Ensembl ID

ENSG00000105409  (ver. 69.37)

Orthologs

Mouse Atp1a3: ENSMUSG00000040907

Human splice variants
Mouse splice variants