CACNA2D2

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Description

calcium channel, voltage-dependent, alpha 2/delta subunit 2

Protein family

Transporters

Chromosome

3:p21.31 (50400233 - 50541675)

Ensembl ID

ENSG00000007402  (ver. 69.37)

Orthologs

Mouse Cacna2d2: ENSMUSG00000010066

Human splice variants
Mouse splice variants