ATP6V0A4

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene are associated with renal tubular acidosis associated with preserved hearing. [provided by RefSeq, Jul 2008]

Description

ATPase, H+ transporting, lysosomal V0 subunit a4

Protein family

Mapped to UniProt SWISS-PROT, Potential transmembrane proteins, Transporters

Chromosome

7:q34 (138391040 - 138484305)

Ensembl ID

ENSG00000105929  (ver. 71.37)

Orthologs

Mouse Atp6v0a4: ENSMUSG00000038600

Human splice variants
Mouse splice variants