MARK4

This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

Description

MAP/microtubule affinity-regulating kinase 4

Protein family

Enzymes, Kinases

Chromosome

19:q13.32 (45582546 - 45808541)

Ensembl ID

ENSG00000007047  (ver. 69.37)

Orthologs

Mouse Mark4: ENSMUSG00000030397

Human splice variants
Mouse splice variants