DGUOK

In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Description

deoxyguanosine kinase

Protein family

Enzymes, Mapped to UniProt SWISS-PROT

Chromosome

2:p13.1 (74153953 - 74186088)

Ensembl ID

ENSG00000114956  (ver. 71.37)

Orthologs

Mouse Dguok: ENSMUSG00000014554

Human splice variants
Mouse splice variants