APOA1

This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. [provided by RefSeq, Jul 2008]

Description

apolipoprotein A-I

Protein family

Candidate cancer biomarkers, Candidate cardiovascular disease genes, Mapped to UniProt SWISS-PROT, Plasma proteins, Potential transmembrane proteins, Potentially secreted proteins

Chromosome

11:q23.3 (116706467 - 116708666)

Ensembl ID

ENSG00000118137  (ver. 71.37)

Orthologs

Mouse Apoa1: ENSMUSG00000032083

Human splice variants
Mouse splice variants